Our scientific
experience

At ATEM we work on transferring cryo-EM science from academia to industrial applications with high availability. Such an endeavor requires an extraordinary team; luckily, we covered that. Our growing ATEM team is filled with passionate people from diverse disciplines: cryo-EM, biochemistry, virology, IT, and machine learning.

We would like to highlight a few of our publications below.

Cell

  • Bertram, K., Agafonov, D.E., Dybkov, O., Haselbach, D., Leelaram, M.N., Will, C.L., Urlaub, H., Kastner, B., Lührmann, R., and Stark, H. (2017). Cryo-EM Structure of a Pre-catalytic Human Spliceosome Primed for Activation. Cell 170, 701–713.e711.
  • Bertram, K., El Ayoubi, L., Dybkov, O., Agafonov, D.E., Will, C.L., Hartmuth, K., Urlaub, H., Kastner, B., Stark, H., and Lührmann, R. (2020). Structural Insights into the Roles of Metazoan-Specific Splicing Factors in the Human Step 1 Spliceosome. Mol. Cell 80, 127-139.

Nature

  • Bertram, K., Agafonov, D.E., Liu, W.-T., Dybkov, O., Will, C.L., Hartmuth, K., Urlaub, H., Kastner, B., Stark, H., and Lührmann, R. (2017). Cryo-EM structure of a human spliceosome activated for step 2 of splicing. Nature 542, 318–323.
  • Zhang, Z., Will, C.L., Bertram, K., Dybkov, O., Hartmuth, K., Agafonov, D.E., Hofele, R., Urlaub, H., Kastner, B., Lührmann L., & Stark, H. (2020). Molecular architecture of the human 17S U2 snRNP. Nature, 583, 310–313.

Science

  • Townsend, C., Leelaram, M.N., Agafonov, D.E., Dybkov, O., Will, C.L., Bertram, K., Urlaub, H., Kastner, B., Stark, H., and Lührmann, R. (2020). Mechanism of protein-guided folding of the active site U2/U6 RNA during spliceosome activation. Science, 370.
  • Schrader, J., Henneberg, F., Mata, R.A., Tittmann, K., Schneider, T.R., Stark, H., Bourenkov, G., Chari, A. (2016) The inhibition mechanism of human 20S proteasomes enables next-generation inhibitor design. Science, 353, 594-598.

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