At ATEM we work on transferring cryo-EM science from academia to industrial applications with high availability. Such an endeavor requires an extraordinary team; luckily, we covered that. Our growing ATEM team is filled with passionate people from diverse disciplines: cryo-EM, biochemistry, virology, IT, and machine learning.
We would like to highlight a few of our publications below.
Bertram, K., Agafonov, D.E., Dybkov, O., Haselbach, D., Leelaram, M.N., Will, C.L., Urlaub, H., Kastner, B., Lührmann, R., and Stark, H. (2017). Cryo-EM Structure of a Pre-catalytic Human Spliceosome Primed for Activation. Cell 170, 701–713.e711.
Bertram, K., El Ayoubi, L., Dybkov, O., Agafonov, D.E., Will, C.L., Hartmuth, K., Urlaub, H., Kastner, B., Stark, H., and Lührmann, R. (2020). Structural Insights into the Roles of Metazoan-Specific Splicing Factors in the Human Step 1 Spliceosome. Mol. Cell 80, 127-139.
Bertram, K., Agafonov, D.E., Liu, W.-T., Dybkov, O., Will, C.L., Hartmuth, K., Urlaub, H., Kastner, B., Stark, H., and Lührmann, R. (2017). Cryo-EM structure of a human spliceosome activated for step 2 of splicing. Nature 542, 318–323.
Zhang, Z., Will, C.L., Bertram, K., Dybkov, O., Hartmuth, K., Agafonov, D.E., Hofele, R., Urlaub, H., Kastner, B., Lührmann L., & Stark, H. (2020). Molecular architecture of the human 17S U2 snRNP. Nature, 583, 310–313.
Townsend, C., Leelaram, M.N., Agafonov, D.E., Dybkov, O., Will, C.L., Bertram, K., rlaub, H., Kastner, B., Stark, H., and Lührmann, R. (2020). Mechanism of protein-guided folding of the active site U2/U6 RNA during spliceosome activation. Science, 370.
Schrader, J., Henneberg, F., Mata, R.A., Tittmann, K., Schneider, T.R., Stark, H., Bourenkov, G., Chari, A. (2016) The inhibition mechanism of human 20S proteasomes enables next-generation inhibitor design. Science, 353, 594-598.
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