Epitope Mapping

Precision insights into molecular interactions to enable rational lead candidate selection and patenting.
100% Ambiguity free results

Leverage the Gold-Standard of Epitope Mapping

We generate precise 3D molecular blueprints of your Antigen-Antibody complex to enable detailed insights for advanced research and development.

Directly Interpretable Results

3D Epitope Mapping provides directly interpretable results and clear insights into the molecular interactions that facilitate the binding and therapeutic effect of your Antibody candidate on the Target Protein. 

100% Results Certainty

Benefit from 100% results certainty when interpreting our data. Antibody-Antigen interactions are traced down to atomic detail, if necessary, avoiding the project crippling ambiguity of less precise, orthogonal methods of epitope mapping.  

Identification of ALL Epitope Types

Paratope Mapping Possible

Identify and characterize the structural interface on the Antibody side of the Target complex. Highly valuable insights for Structure Based Drug design and Patenting applications. 

Gain answers with confidence

Where does my Antibody bind the Target/Antigen?
What Amino Acids exactly are involved in Antibody binding?
Are my Antibodies sterically competing for the same or adjacent Target binding sites?
Does my Antibody affect the 3D Structure of the Antigen?
Does my Antibody affect the Stability of the Antigen?
Does my Antibody affect the Multimerization Status of the Antigen?
The ATEM 3D Epitope mapping options

Generate key insights at Medium-or-High resolution level

ATEM offers two analysis options to meet your budget and timeline requirements.

Medium Resolution

Ideal for rational lead candidate selection.

Includes:
Fast & Economical
Option 1

High Resolution

Ideal for high-end Mode of Action studies, lead optimization, IND filings, & patent applications.

Includes:
Maximal Structural Details
Option 2
Customer Satisfaction: Our Top Priority

Work with a trusted, professional provider

We are dedicated to providing an exceptional service, while our scientists guide you through the entire process

More than
20 studies
performed in 2024
Turnaround times of
4-6 weeks
possible*
Highest
success
rates
streamlined & transparent process

Project workflow

We ensure that your project is completed on time, within budget, and to your highest satisfaction. Here’s a step-by-step overview of how our process works.

1. Pilot Phase
An initial cryo-EM​ Pilot Study​ ensures that all sample materials are of sufficient quality for subsequent 3D epitope mapping procedures. 
2. Biochemical Optimization
(if necessary)
Biochemical optimization work to improve structural homogeneity of the Target complexes (if required).
3. Medium Resolution 3D Epitope Mapping Phase
Generate Medium Resolution 3D Epitope Mapping Results.
4. High ​ Resolution 3D Epitope Mapping Phase
Conclude with High Resolution 3D Epitope Mapping Data of the Target complex.
Our Options

Key insights, tailored to your needs

We recognize that every client has unique needs and preferences. Explore our dedicated options to make your project benefit from readily available Gold Standard 3D Epitope Mapping data.  

Option 1
Medium Resolution
Option 2
High Resolution

Curious to learn more about ATEM’s 3D Epitope mapping services?