Search
Close this search box.

Viral vector
analytics

Viral vector analysis

Adeno-associated virus-like particles (AAV) have become a popular method of gene delivery, paving the way for gene therapies, including CRISPR/Cas9 editing.

Unfortunately, not all viral particles are correctly packed after production, lacking the important DNA payload. Accurately determining the capsid “fill-ratio” of viral vector delivery systems is thus essential for the development and manufacture of safe and reliable drug products.

Get precise viral vector fill rate analysis with cryo-EM technology

ATEM’s cryo-EM technology gives you statistically valid, highly accurate insights into the full and empty capsid ratio of your sample with single-particle precision. Not only that – we can show you the fraction of partially filled particles in your sample.

We ensure the most reliable results for your project through rapid turnaround times and the highest quality standards under GMP regulations.

Identify and quantify

Key application areas

Application examples

AT THE FOREFRONT OF
INDUSTRIAL CRYO-EM TECHNOLOGY

LET'S DISCUSS YOUR PROJECT

 

Quantify empty AAV particles

 

Filled AAV particles

 

Intermediates between empty and filled.

Our in-house method
of fill rate analysis

We successfully developed a method that allows us to distinguish between empty/intermediate/full capsids. You can read the full version of our case study here.

Our AAV Analysis at a glance
Quick analysis time & extensive support

Feasibility study

01

Cryo-EM screening

02

Data collection and processing

03

Results

Formalized report including:

04

Sample requirements

We prepare everything else! We receive your sample – optimize and test it, before returning the data in a personalized way that suits you.

Sample amounts

Get insight into detailed parameters with sample amounts of only 30-50 μl.

Express anaylsis

First results in 20 days or faster.

Results

Receive an extensive report, custom made to highlight areas of interest.