Lipid nanoparticle(LNP) analysis has become one of the most promising drug delivery systems. While molecules like RNA are too big and fragile to enter the cell alone, encapsulating them into nanoparticles allows efficient entry into cells, providing a safe and effective delivery method. The cells do the rest of the job—producing proteins that lead to long-lasting immunity.
The method gained a lot of traction in the last years because of the COVID-19 mRNA vaccines, but this is only the beginning. The future holds a lot of promises – not only for vaccines, but the production of entirely new therapies.
Sample quality control can be a laborious process. Visual EM data and statistics can help estimate the sample quality in a way no other method can. With our LNP analysis, we offer insight into LNP size and morphology, and highlight features such as blebbing or other unwanted features. It can also rule out sample contamination and other undesired properties, saving time by selecting the most viable target immediately.
Compared to methods like dynamic light scattering (DLS), structural characterization requires a low sample volume (20-50 µl instead of 20 ml), and is unaffected by impurities.
We have analysed LNPs from the Comirnaty COVID-19 vaccine in our case study. You can download it for more information here.
We prepare everything else! We receive your sample – optimize and test it, before returning the data in a personalized way that suits you.
Get insight into detailed parameters with sample amounts of only 20-50 μl.
Get first results in 20 days or faster.
Receive an extensive, custom-made report that highlights any areas of interest.