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Epitope mapping

3D EPITOPE MAPPING BY CRYO-EM

Benefit from our unique, high-throughput cryo-EM platform, and discern challenging epitopes in 3D. With the possibilities of cryo-EM, you can screen several FAB/mAbs in complex with your target to visualize conformations, contacting residues, and binding locations.

Non-linear epitopes are difficult to discern by traditional approaches. Open fresh possibilities with structural information and discover distinctions critical for antibody development. Structural epitope mapping leads to effective drug design and innovation. With the recent pandemic in mind, it has never been more important to screen novel antibodies to seek out the most viable solutions at rapid speed.

Benefit from 3D epitope mapping

Application areas

Application examples

AT THE FOREFRONT OF
INDUSTRIAL CRYO-EM TECHNOLOGY

LET'S DISCUSS YOUR PROJECT

Our 3D epitope mapping
for high-resolution

Feasibility study

01

Screening campaign

02

Data collection and processing

03

Results

04

Sample requirements

We prepare everything else! We receive your sample – optimize and test it, before returning the data in a personalized way that suits you.

Sample amounts

Get insight into detailed parameters with sample amounts of only 30-50 μl (>0.5 mg/ml).

Turnaround times

Get first results within 2 to 4 weeks.
depending on #compounds

Results

Receive a 3D structure together with a ready-to-use PDB file, including an extensive report.